Adjunct Professor
Fields of Interest
Biography
My lab studies microtubule dynamics, microtubule motors and chromosome segregation. We use human and mammalian cell lines to investigate the impact of microtubule motors and regulators of microtubule polymerization on the fidelity of cell division and chromosome instability. We use high resolution and super-resolution live cell imaging and total internal fluorescence (TIRF) microscopy in conjunction with fluorescent proteins, bio-sensors and gene-edited cell lines to investigate dynamic processes that govern chromosome segregation during mitosis.
Positions:
2015 - Adjunct Professor of Biology, University of Washington
2006 - Professor of Physiology & Biophysics, University of Washington
2000 - Associate Professor of Physiology & Biophysics, University of Washington
1994 - Assistant Professor of Physiology & Biophysics, University of Washington
Education:
1988-1994: Postdoctoral Fellow; University of California, San Francisco
1988: PhD; Zoology, University of California, Berkeley
1982: BA+Honors; Molecular Biology, University of California, Berkeley
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Selected Research
- Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells., Wordeman Linda, Ertych Norman, Stolz Ailine, Stenzinger Albrecht, Weichert Wilko, Kaulfuß Silke, Burfeind Peter, Aigner Achim, and Bastians Holger, Nature cell biology, 2014 Aug, Volume 16, Issue 8, p.779-91 (2014)
- Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo, Wordeman Linda, Schumpert Brenda, Garcia Guadalupe, Wessel Gary M., and Hille Merrill B., Mechanisms of Development, Jan-04-2013, Volume 130, Issue 4-5, p.290 - 303 (2013)
- MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment., Wagenbach Michael, Wordeman Linda, Domnitz Sarah B, and Decarreau Justin, The Journal of cell biology, 2012 Apr 16, Volume 197, Issue 2, p.231-7 (2012)
- Kif18A and chromokinesins confine centromere movements via microtubule growth suppression and spatial control of kinetochore tension., Stumpff Jason, Wagenbach Michael, Franck Andrew, Asbury Charles L, and Wordeman Linda, Developmental cell, 2012 May 15, Volume 22, Issue 5, p.1017-29 (2012)
- Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK., Wagenbach Michael, Asbury Charles L, Wordeman Linda, and Cooper Jeremy R, Nature structural & molecular biology, 2010 Jan, Volume 17, Issue 1, p.77-82 (2010)
- Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow., Wordeman Linda and Rankin Kathleen E, The Journal of cell biology, 2010 Jul 12, Volume 190, Issue 1, p.35-43 (2010)
- The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment., Stumpff Jason, Wagenbach Michael, Wordeman Linda, von Dassow George, and Asbury Charles, Developmental cell, 2008 Feb, Volume 14, Issue 2, p.252-62 (2008)