Phylogenomic Analysis of the Ranunculales resolves branching events across the order

Poppies (Papaver), columbines (Aquilegia), buttercups (Ranunculus) and related species, are members of the order Ranunculales, the sister lineage to all other eudicots. Using coalescent and concatenated methods on 882 putatively single copy genes, we have developed a robust phylogeny including 27 species representing all major lineages within the Ranunculales and all tribes within the Papaveraceae.

Student perception of group dynamics predicts individual performance: Comfort and equity matter

Active learning in college classes and participation in the workforce frequently hinge on small group work. However, group dynamics vary, ranging from equitable collaboration to dysfunctional groups dominated by one individual. To explore how group dynamics impact student learning, we asked students in a large-enrollment university biology class to self-report their experience during in-class group work. Specifically, we asked students whether there was a friend in their group, whether they were comfortable in their group, and whether someone dominated their group.

Identification and Validation of Small- Gatekeeper Kinases as Drug Targets in Giardia lamblia

Giardiasis is widely acknowledged to be a neglected disease in need of new therapeutics to address toxicity and resistance issues associated with the limited available treatment options. We examined seven protein kinases in the Giardia lamblia genome that are predicted to share an unusual structural feature in their active site. This feature, an expanded active site pocket resulting from an atypically small gatekeeper residue, confers sensitivity to ªbumpedº kinase inhibitors (BKIs), a class of compounds that has previously shown good pharmacological properties and minimal toxicity.
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